SCIENTIFIC REFERENCE LIST

  • T.Kubasova, M.Horvath, K. Kocsis and M.Fenyö: Effect of visible light on some cellular and immune parameters. Immunology and Cell Biology, 1995, 73; 239-244.
  • M.Fenyö, J.Mandl and A.Falus: Opposite effect of linearly polarized light on biosynthesis of interleukin-6 in a human B lymphoid cell line and peripheral human monocytes. Cell Biology International, 2002, 26(3); 265-269.
  • T.Kubasova, M.Fenyö, Z.Somosy, L.Gazso and I.Kertesz: Investigations on biological effect of polarized light. Photochemistry and Photobiology, 1988, 48; 505-509.
  • P.Bolton, M.Dyson and S.Young: The effect of polarized light on the release of growth factors from the U-937 macrophage-like cell line. Laser Therapy, 1992, 2(3); 33-37.
  • I.Kertesz, M.Fenyö, E.Mester and G.Bathory: Hypothetical physical model for laser dissimulation. Optics and Laser Technology, 1982, 16; 31-32.
  • K.A.Samoilova, K.D.Obolenskaya, A.V.Vologdina, S.A.Snopov and E.V.Shevchenko: Single skin exposure to visible light induces rapid modification of entire circulation blood - 1. Improvement of rheologic and immune parameters. Progress in Biomedical Optics/Proceedings of Low-Power Light on Biological Systems, 1998, IV; 90-103.
  • J.E.Roberts: Visible light induces changes in the immune response through an eye-brain mechanism (photoneuroimmunology), Journal of Photochemistry and Photobiology, B: Biology, 1995, 29(1); 3-15.

Wound

  • L.Medenica and M.Lens: The use of polarised polychromatic non-coherent light alone as a therapy for venous leg ulceration. Journal of Wound Care, 2003, 12(1); 37-40.
  • S.Monstrey, H.Hoeksema, H.Saelens, K.Depuydt, M.Hamdi, K.Van Landuyt and P.Blondeel: A conservative approach for deep dermal burn wounds using polarised-light therapy. British Journal of Plastic Surgery, 2002, 55; 420-426.
  • P.Iordanou, G.Baltopoulos, M.Giannakopoulou, P.Bellou and E.Ktenas: Effect of polarized light in the healing process of pressure ulcers. International Journal of Nursing Practice, 2002, 8(1); 49-55.
  • S.Monstrey, H.Hoeksema, K.Depuydt, G.Van Maele, K.Van Landuyt and P.Blondeel: The effect of polarized light on wound healing. European Journal of Plastic Surgery, 2002, 24(8); 377-382.
  • Invited commentary: W.Vanscheidt, The effect of polarized light on wound healing. European Journal of Plastic Surgery, 2002, 24(8); 383.
  • Colic MM, Vidojkovic N, Jovanovic M, Lazovic G. The use of polarized light in aesthetic surgery. Aesthetic Plast.Surg. 2004;28(5):324-7.
  • Tomashuk IP, Tomashuk II. [Clinical efficacy of alprostan in combination with "Bioptron-II" rays and iruxol-miramistin in the treatment of the diabetic foot complicated by atherosclerosis]. Klin.Khir. 2001;(8):49-51.
  • Aragona SE, Grassi FR, Nardi G, Lotti J, Mereghetti G, Canavesi E, Equizi E, Puccio AM , Lotti T. Photobiomodulation with  polarized light  in  the  treatment  of  cutaneous  and  mucosal  ulcerative lesions. J Biol Regul Homeost Agents 2017;31:213-8.
  • Białożyt J., Materniak K., Kawecki M. 2018 Use of polarise lighting  in support of treatment of pressure ulcers among patients after burns. Preliminary report. Dermatologia Estetyczna.  vol.20, 1 (114)
  • Bolton P., Dyson M., Young S. The effect of polarized light on the release  of  growth  factors  from  the  U-937  macrophage-like  cell line. J-STAGE/ Laser therapy, 1992 - / Volume 4 (1992) Issue 1
  • De  Melo  CA,  Alves  AN,  Terena  SM,  Fernandes  KP,  Nunes  FD, da  Silva  Dde  F,  Bussadori  SK,  Deana AM,  Mesquita-Ferrari  RA. Light-emitting   diode   therapy   increases   collagen  deposition during the repair process of skeletal muscle. Lasers Med Sci. 2016 Apr;31(3):531-8.
  • Falus A, M. Fenyo M, Eder K, Madarasi A. Genome-wide gene expression study indicates the anti-inflammatory effect of polarized light  in  recurrent  childhood  respiratory  disease.  Inflamm.  Res. (2011) 60: 965.
  • Fenyö M., Mandl J., Falus A. Opposite effect of linearly polarized light on biosynthesis of interleukin-6 in a human b lymphoid cell line and peripheral human monocytes. Cell Biology International, 1992 Volume26, Issue 3, P.265-269
  • Gasparyan  LV,  Brill  G,  Makela  AM  -  Activation  of  angiogenesis  under  influence  of  red  low  level  laser  radiation  Proceedings Volume 5968, Laser Florence 2005: A Window on the Laser Medicine World; 596806
  • Karu   TI,   Pyatibrat   LV,   Afanasyev   NI.   A   Novel   Mitochondrial   Signaling   Pathway  Activated   by   Visible-to-near   Infrared Radiation Photochemistry and Photobiology, 2004, 80: 366-372
  • Karu,  Kolyakov  SF  Exact  action  spectra  for  cellular  responses relevant  to  phototherapy.  Photomedicine  and  Laser  Therapy, 2005, Volume 23, Number 4, Pp. 355-361
  • Kislyi  ND  (2009)  BIOPTRON  Light  Therapy  in  Dermatocosmetology.  Guideline  of  the  Federal  Educational  Agency  /  Russian People’s Friendship University, Moscow 2009
  • Kolenko 2017 Light therapy in complex treatment of patiens with herpes zoster. National Medical University named after O.O. Bogomolets, Kiev, Ukraine
  • Kubasova T,  Horváth M,  Kocsis K, Fenyö M. Effect of visible light on some cellular and immune parameters. Immunology and Cell Biology (1995) 73, 239-244
  • Lavi  R,  Shainberg  A,  Friedmann  H,  Shneyvays  V,  Rickover  O, Eichler  M,  Kaplan  D,  Lubart R.  Low  energy  visible  light  induces reactive oxygen species generation and stimulates an increase of intracellular calcium concentration in cardiac cells. J Biol Chem. 2003 Oct17;278(42):40917-22.
  • Opel D. R., Hagstrom E., Pace A. K., Sisto K., Hirano-Ali S. A., Desai S.,  &  Swan  J.  (2015).  Light-emitting  Diodes:  A  Brief  Review  and Clinical Experience. The Journal of Clinical and Aesthetic Dermatology, 8, 36–44.
  • Papageorgiou  P,.Katsambas  A,  Chu,A  Phototherapy  with  blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris Britisli Journal of Dermatology 2000: 142: 973-978
  • Roberts JE. Visible light induced changes in the immune response through  an  eye-brain  mechanism  (photoneuroimmunology).  J Photochem Photobiol B. 1995 Jul;29(1):3-15.
  • Samoilova  Ka.,  Zhevago  NA,  Menshutina  MA,  Grigorieva  NB Role of Nitric Oxide in the Visible Light-Induced Rapid Increase of Human Skin Microcirculation at the Local and Systemic Level. Photomedicine and Laser Surgery,  2008, Vol. 26, No. 5
  • Schindl A, Merwald H,.Schindl L, Kaun ‘C And.Wojta J Direct stimulatory effect of low-intensity 670 nm laser irradiation on human endothelial cell proliferation Britisli Journal of Dermatology 2003; 148: 334-336.
  • Young  S,  Bolton  P,  Dyson  M,  Harvey  W,  Diamantopoulos  C. Macrophage responsiveness to light therapy. Lasers Surg Med. 1989;9(5):497-505
  • Zhevago N.A., Samoilova K.A. (2006) Pro- and anti-inflammatory cytokine content in the human peripheral blood after its transcutaneous  and  direct  (in  vitro)  irradiation  with  polychromatic visible  and  infrared  light.  Photomedicine  and  Laser  Surgery.  2006.  Vol. 24(2).  P.129-139.
  • Zhevago N.A., Samoilova K.A., Calderhead R.G. (2006) Polychromatic light similar to the terrestrial solar spectrum without its UV component stimulates DNA synthesis in human peripheral blood lymphocytes in vivo and in vitro. Photochemistry Photobiology. 2006. – Vol. 82(5). – P.1301-1308.

SPORTS MEDICINE

  • Stasinopoulos D, Stasinopoulos I (2006) Comparison of effects of Cyriax physiother-apy, a supervised exercise programme and polarised polychromatic non-coherent light (Bioptron light) for the treatment of lateral epicondylitis. Clinical Rehabilitation 2006; 20: pp 12-23
  • Stasinopoulos  D,  Stasinopoulos  I,  Pantelis  M,  Stasinopoulou  K  (2009)  Comparing  the  effects  of  exercise  program  and  low-level  laser therapy  with  exercise  program  and  polarised  polychromatic  noncoherent  light  (BIOPTRON  light)  on  the  treatment  of  lateral  elbow  tendinopathy. Photomed laser surg 2009 Jun; 27(3): pp 513-520
  • Samoilova K.A., Zubanova O.I., Snopov S.A., Mukhuradze N.A., Mikhelson V.M. (1998) Single skin exposure to visible polarized light induces rapid  modification  of  entire  circulating  blood.  2.  Appearance  of  soluble  factors  restoring  proliferation  and  chromosome  structure  in X-damaged lymphocytes. – Proc. SPIE, 1998, 3569: 26-33.
  • Samoilova  KA,  Bogacheva  ON,  Obolenskaya  KD,  Blinova  MI,  Kalmykova  NV,  Kuz-minikh  EV  (2004)  Enhancement  of  the  blood  growth promoting activity after exposure of volunteers to visible and infrared polarized light. Part I: stimulation of human keratinocyte proliferation in vitro. Photochem Photobiol Sci 2004 Jan; 3(1): pp 96-101
  • Tamarova  ZA,    Limansky YP1,  Gulyar  SA.  (2009)  Antinociceptive  effects  of  color  polarized  light  in  animal  with  formalin  test.  Fiziol.  J.-2009.-V55, N§°3 – P.81-93
  • Wells J, Konrad P, Kao C, Jansen ED, Mahadevan-Jansen A. Pulsed laser versus electrical energy for peripheral nerve stimulation. J. Neurosci. Methods. Jul 2007. 163(2): 326–337.
  • Zlatkovic-Svenda MI, Leitner C, Biljana Lazovic BL , Petrovic DM. (2018) Complex Regional Pain Syndrome (Sudeck Atrophy) Prevention  Possibility  and  Accelerated  Recovery  in  Patients  with  Distal  Radius  at  the  Typical  Site  Fracture  Using  Polarized,  Polychromatic  Light
  • Therapy. Photobiomodulation, Phototherapy, and Laser Surgery Volume 37, N4.

Pain

  • M.F.Ballyzek, V.Vesovic-Potic, X.He, A.Johnston: Efficacy of polarized, polychromatic, non-coherent light in the treatment of chronic musculoskeletal neck and shoulder pain. Unpublished material, BIOPTRON AG, Wollerau, Switzerland (2005).
  • Stasinopoulos D. The use of polarized polychromatic non-coherent light as therapy for acute tennis elbow/lateral epicondylalgia: a pilot study. Photomedicine and Laser Surgery 2005;23(1):66-69.
  • D.Stasinopoulos, I.Stasinopoulos and M.I.Johnson: Treatment of carpal tunnel syndrome with polarized polychromatic noncoherent light (Bioptron light): a preliminary, prospective, open clinical trial. Photomedicine and Laser Surgery, 2005;23(2):225-228.
  • I.Stasinopoulos: Report of the rheumatology and rehabilitation centre. Unpublished material, Greece (1990).
  • Lymans'kyi I, Tamarova ZA, Huliar SO. [Suppression of visceral pain by action of the low intensity polarized light on acupuncture antinociceptive points]. Fiziol.Zh. 2003;49(5):43-51.
  • Ballyzek M.F.,Vesovic-Potic V, He X, Johnston A. (2005) Efficacy of polarized, polychromatic, non-coherent light in the treatment of chronic  musculoskeletal neck and shoulder pain. Unpublished material, BIOPTRON AG, Wollerau, Switzerland (2005).
  • Bjordal JM , Couppé C , Chow  RT , Tunér J and  Ljunggren EA. (2003) A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders. Australian Journal of Physiotherapy.  Vol. 49, P107-116 .
  • Gulyar S.A., Z.A. Tamarova. (2017)  Analgesic Effects of the Polarized Red+Infrared LED Light. Journal of US-China Medical Science 14 (2017) 47-57
  • Gulyar S.A., Z.A. Tamarova. (2019)  Comparison of the Analgesic Effect of Low-Intensive Polarized Polychromatic Light and Analgesics. Journal of US-China Medical Science 16 (2019) 1-15
  • Obolenskaya K.D., Samoilova K.A (2002). Comparative study of effects of polarized and non-polarized light on human blood in vivo and in vitro. I. Phagocytosis of monocytes and granulocytes. Laser Technology. –2002 – Vol. 12(2-3). P.7-13.
  • Petruzzi M, GM, Cocco F, della Vella F, Grassi R, Grassi FR. (2019) Polarized Polychromatic Noncoherent Light (Bioptron Light) as Adjunctive Treatment in Chronic Oral Mucosal Pain: A Pilot Study. Photobiomodulation, Photomedicine, and Laser SurgeryVol. 37, No. 4
  • Bjordal JM , Couppé C , Chow  RT , Tunér J and  Ljunggren EA. (2003) A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders. Australian Journal of Physiotherapy.  Vol. 49, P107-116
  • Fulga C. Antiinflammatory effect of laser therapy in rheumatoid arthritis. Rom J Intern Med. 1998. 36(3-4): 273-279.

Dermatology

  • Aronis, A.Braziotis, K.Kafouros, N.Pagratis, Th.Papakostas and P.Venetsanos: The action of visible polarized light on skin diseases. Poster presentation at the 18th International Congress of Dermatology, New York, USA (1992).
  • Bartos Z.; The use of the BIOPTRON Light Therapy System in the treatment of skin disorders; Kiskunfélegyháza City Hospital and Polyclinic Department of Dermatological and Venerreal Diseases; Experience report; Hungary (2004).
  • Charakida Aikaterini, Deaton Edward D. Charakida Marietta, Mouser Paul et al.; Phototherapy in the Treatment of Acne Vulgaris. What is the Role?; Am J Clin Dermatol; 5(4):211-216(2004).
  • Bolton P., Dyson M., Young S. The effect of polarized light on the release of growth factors from the U-937 macrophage-like cell line. J-STAGE/ Laser therapy, 1992 - / Volume 4 (1992) Issue 1
  • Zhevago N.A., Samoilova K.A. (2006) Pro- and anti-inflammatory cytokine content in the human peripheral blood after its transcutaneous and direct (in vitro) irradiation with polychromatic visible and infrared light. Photomedicine and Laser Surgery. – 2006. – Vol. 24(2). – P.129-139.
  • Zhevago N.A., Samoilova K.A., Calderhead R.G. (2006) Polychromatic light similar to the terrestrial solar spectrum without its UV component stimulates DNA synthesis in human peripheral blood lymphocytes in vivo and in vitro. Photochemistry Photobiology. – 2006. – Vol. 82(5). – P.1301-1308.
  • Fenyö M., Mandl J., Falus A. Opposite effect of linearly polarized light on biosynthesis of interleukin‐6 in a human b lymphoid cell line and peripheral human monocytes. Cell Biology International, 1992 Volume26, Issue 3, P.265-269
  • Gasparyan LV, Brill G, Makela AM - Activation of angiogenesis under influence of red low level laser radiation Proceedings Volume 5968, Laser Florence 2005: A Window on the Laser Medicine World; 596806
  • Samoilova Ka., Zhevago NA, Menshutina MA, Grigorieva NB Role of Nitric Oxide in the Visible Light-Induced Rapid Increase of Human Skin Microcirculation at the Local and Systemic Level. Photomedicine and Laser Surgery,  2008, Vol. 26, No. 5
  • Karu TI, Pyatibrat LV, Afanasyev NI. A Novel Mitochondrial Signaling Pathway Activated by Visible-to-near Infrared Radiation Photochemistry and Photobiology, 2004, 80: 366-372
  • Karu, Kolyakov SF Exact action spectra for cellular responses relevant to phototherapy. Photomedicine and Laser Therapy, 2005, Volume 23, Number 4, Pp. 355-361
  • Kubasova T,  Horváth M,  Kocsis K, Fenyö M. Effect of visible light on some cellular and immune parameters. Immunology and Cell Biology Volume73, Issue3, June 1995, Pages 239-244
  • Lavi R, Shainberg A, Friedmann H, Shneyvays V, Rickover O, Eichler M, Kaplan D, Lubart R. Low energy visible light induces reactive oxygen species generation and stimulates an increase of intracellular calcium concentration in cardiac cells. J Biol Chem. 2003 Oct 17;278(42):40917-22.
  • Roberts JE. Visible light induced changes in the immune response through an eye-brain mechanism (photoneuroimmunology). J Photochem Photobiol B. 1995 Jul;29(1):3-
  • Schindl A, Merwald H,.Schindl L, Kaun 'C And.Wojta J Direct stimulatory effect of low-intensity 670 nm laser irradiation on human endothelial cell proliferation Britisli Journal of Dermatology 2003; 148: 334-336.
  • Young S, Bolton P, Dyson M, Harvey W, Diamantopoulos C. Macrophage responsiveness to light therapy. Lasers Surg Med. 1989;9(5):497-505
  • De Melo CA, Alves AN, Terena SM, Fernandes KP, Nunes FD, da Silva Dde F, Bussadori SK, Deana AM, Mesquita-Ferrari RA. Light-emitting diode therapy increases collagen deposition during the repair process of skeletal muscle. Lasers Med Sci. 2016 Apr;31(3):531-8.
  • Opel D. R., Hagstrom E., Pace A. K., Sisto K., Hirano‐Ali S. A., Desai S., & Swan J. (2015). Light‐emitting Diodes: A Brief Review and Clinical Experience. The Journal of Clinical and Aesthetic Dermatology, 8, 36–44.
  • Colic, M.M., Vidojkovic N , Jovanovic, M., Lazovic, G The Use of Polarized Light in Aesthetic Surgery. Aesth. Plast. Surg. 28:324-327, 2004
  • Papageorgiou P,.Katsambas A, Chu,A Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris Britisli Journal of Dermatology 2000: 142: 973-978
  • Kislyi ND (2009) BIOPTRON Light Therapy in Dermatocosmetology. Guideline of the Federal Educational Agency / Russian People’s Friendship University, Moscow 2009.
  • Kolenko 2017 Light therapy in complex treatment of patiens with herpes zoster. National Medical University named after O.O. Bogomolets, Kiev, Ukraine

Pediatric

  • Burkin IA, Okateyev VS, 2004. The use of BIOPTRON Light Therapy in the treatment of children with musculoskeletal injuries. Clinical Experience Report. Traumatology Department, Sperandsky; Municipal Children's Hospital, Moscow, Russia.
  • Cerná O. The BIOPTRON Light Therapy in the life support and intensive care unit, Abstract, Congress Proceedings, Prague, Czechoslovakia 2005.
  • Khan MA, 2001, Report on use of BIOPTRON polychromatic incoherent polarized light in paediatrics, Experience Report. Russian Scientific Centre of Reconstructive Medicine and Balneotherapy, Moscow, Russia.
  • Khan MA, Erdes SI. Clinical efficiency of BIOPTRON polychromatic polarized light in the treatment of atopic dermatitis and frequent respiratory diseases in children, Allergology and Immunology in Paediatrics, N3 (14), September 2008.

SAD

  • Avery DA, Kizer D, Bolte MA et al.: Bright light therapy of subsydromal seasonal affective disorders in the workplace: morning vs. afternoon exposure. Acta Psychiatrica Scandinavica 2001; 103:267 -274.
  • Eastrnan Cl, Young MA, Fogg LF, Lìu L, Meaden PM: Bright light treatment of winter depression: a placebo-controlled trial. Arch Gen Psychiatry 1998; 55: BB3 - 889.
  • Lam RW and Levitt A: Canadian Consensus Guidelines for the Treatment of SAD, A Summary of the Report of the Canadian Consensus Group on SAD, Can J Diagnosis 1998; Suppl. 1 - l5.
  • Lee TM, Chan CC: Dose-response relationship of phototherapy for seasonal affective disorder: a meta'analysis. Acta Psychiatr Scand 1999; 99; 315 – 323.